Spray polyurethane foam, or SPF, is the main type of 2-part, closed-cell spray foam used by insulation contractors. Large-scale insulation jobs require special equipment as well as safety gear to protect the installer from chemical fumes during installation. When the foam cures and hardens just several minutes after application, it's completely safe for as long as it stays in place.
Most closed-cell spray foam is now formed using hydrofluorocarbon (HFC) blowing agents that have high global warming potential, partially or completely offsetting the climate benefits of the energy savings they can offer. In the United States, HFCs are scheduled to be phased out by January, 2021. A few spray foam suppliers have started supplying spray foam blown with hydrofluoroolefin (HFO) blowing agents without this problem as of early 2017.